3-Methyl-5-nitroisoquinoline → 3-Methylisoquinolin-5-amine

HRID 970666노트

반응식

HRID 970666 반응식
[CH3:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[C:9]([N+:12]([O-])=O)[CH:8]=[CH:7][CH:6]=2>[Pd].CO>[NH2:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:11]=[C:2]([CH3:1])[N:3]=[CH:4]2

참가 물질

4

반응물 1

HCID 2749733-Methyl-5-nitroisoquinoline

생성물 1

HCID 122120553-Methylisoquinolin-5-amine수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 3-methyl-5-nitroisoquinoline (1.3 g, 0.0069 mol—prepared according to the procedure in WO 2004/024710), 10% Pd—C (100 mg) and MeOH (100 mL) was stirred under an atmosphere of hydrogen (1 atm) at rt for 2 h. The mixture was filtered and the filtrate was concentrated under vacuum to give a light yellow solid (1.1 g, 100%). LC-MS: 0.64 min, 159.1 (M+1).

후처리

  1. customprepared
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-709cf56b5bcc40f6b489085696e63440
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312233B2

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