4-Phenethyloxybenzoic Acid Methyl Ester → (4-Phenethyloxyphenyl)methanol

HRID 970787노트

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HRID 970787 반응식
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:6][CH:5]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C(OCC)C>[CH2:11]([O:10][C:7]1[CH:6]=[CH:5][C:4]([CH2:3][OH:2])=[CH:9][CH:8]=1)[CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 120638344-Phenethyloxybenzoic Acid Methyl EsterHCID 21226445Aluminium lithium hydride

생성물 1

HCID 12990905(4-Phenethyloxyphenyl)methanol수율 98.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

4-Phenethyloxybenzoic acid methyl ester 10 (7.66 g, 29.89 mmol) was dissolved in diethyl ether and chilled to 0° C. LiAlH4 was slowly added and allowed to stir at 0° C. for 3 hours. The mixture was quenched with H2O. After addition of 3N NaOH the mixture was allowed to stir for 30 min. The mixture was then acidified with 4.5N HCl, extracted, dried, and concentrated in vacuo to give about 6.7 g of a crystalline (4-phenethyloxyphenyl)methanol 11.

후처리

  1. customThe mixture was quenched with H2O
  2. additionAfter addition of 3N NaOH the mixture
  3. stirringto stir for 30 min
  4. extractionextracted
  5. customdried
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b73287181d294dbcbbad791e91949adc
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312230B2

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