Cesium acetate → Acetic Acid 2-phenylbenzoxazol-5-ylmethyl Ester

HRID 970816

반응식

HRID 970816 반응식
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:17]=1.[C:18]([O-:21])(=[O:20])[CH3:19].[Cs+]>CN(C=O)C>[C:11]1([C:9]2[O:10][C:6]3[CH:5]=[CH:4][C:3]([CH2:2][O:21][C:18](=[O:20])[CH3:19])=[CH:17][C:7]=3[N:8]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 5152919Cesium acetateHCID 220628305-Bromomethyl-2-phenylbenzoxazole

생성물 1

HCID 23581212Acetic Acid 2-phenylbenzoxazol-5-ylmethyl Ester수율 101.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-Bromomethyl-2-phenylbenzoxazole 56 (1.0 g, 3.4 mmol) and cesium acetate (1.33 g, 6.94 mmol) were stirred together in DMF(25 ml) under an atmosphere of N2 overnight. The DMF was evaporated under high vacuum and the residue partitioned between ethyl acetate (100 ml) and water (100 ml). The ethyl acetate layer was separated then washed and dried. Evaporation of the solvent yielded 920 mg of acetic acid 2-phenylbenzoxazol-5-ylmethyl ester 57.

후처리

  1. customThe DMF was evaporated under high vacuum
  2. customthe residue partitioned between ethyl acetate (100 ml) and water (100 ml)
  3. customThe ethyl acetate layer was separated
  4. washthen washed
  5. customdried
  6. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-31328c837bef439eb38fa3f8aab89051
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312230B2

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