반응식
[OH:1][CH2:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][NH:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:10])=[CH:5][CH:4]=1.CCN(CC)CC.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:9]([NH:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][O:1][S:27]([CH3:26])(=[O:29])=[O:28])=[CH:18][CH:17]=1)=[O:10]참가 물질
4
실험 절차
Using General Procedure G: Reaction of pyridine-2-carboxylic acid 4-hydroxymethyl-benzylamide (200 mg, 0.83 mmol), Et3N (144 uL, 0.99 mmol), and MsCl (71 uL, 0.91 mmol) for 10 minutes at 0° C. gave the title compound (214 mg, 81%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 2.92 (s, 3H), 4.69 (d, 2H, J=3.3 Hz), 5.23 (s, 2H), 7.41-7.47 (m, 5H), 7.85-7.87 (m, 1H), 8.24 (d, 1H, J=7.8 Hz), 8.50 (br s, 1H), 8.54 (d, 1H, J=3.9 Hz).
출처 및 근거
- ORD 기록
- ord-7104b78b5c604691a0a8e831e384fd0b
- 출처 데이터셋
- uspto-grants-2007_12
- 특허 번호
- US07312234B2
연결된 노트
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