Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 10165721, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | pyridine-2-sulfonic acid 4-({(5,6,7,8-tetrahydro-quinolin-8-yl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-ylmethyl]-amino}-methyl)-benzylamide | HCID 68896453 | — |
| 생성물 | HCID 10165721 | HCID 10165721 | 85% |
반응 단계
Using General Procedure E: Reaction of pyridine-2-sulfonic acid 4-({(5,6,7,8-tetrahydro-quinolin-8-yl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-ylmethyl]-amino}-methyl)-benzylamide (100 mg, 0.15 mmol); and 6N HCl (3.9 mL) for 3 h at 50° C. followed by column chromatography on silica gel (CH2Cl2/MeOH/NH4OH: 94:3:3) gave the title compound (68 mg, 85%) as a white foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07312234B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-35673e6604e549e4a601619e1897937a |
| 출처 메모 | uspto-grants-2007_12 |