Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 3-formyl-1H-indole-7-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Methyl indole-7-carboxylate | HCID 676694 | — |
| 생성물 | Methyl 3-formyl-1H-indole-7-carboxylate | HCID 762965 | — |
반응 단계
2.9 ml of phosphorus oxychloride are added slowly to 7 ml of N,N-dimethylformamide in a nitrogen atmosphere (formylation solution). 5 g (0.029 mol) of methyl indole-7-carboxylate are dissolved in 7 ml of DMF and added slowly to the formylation solution, during which the temperature does not rise above 30 degrees. The mixture is then warmed at 100° for one hour. After cooling, the mixture is poured into water and neutralised using sodium hydroxide solution, and the deposited crystals are filtered off with suction. m.p. 154°. Yield 5.3 g (89.9% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07312342B2 |
| 출처 데이터셋 | uspto-grants-2007_12 |
| ORD ID | ord-76817f835db14e368bc637b54cebb03a |
| 출처 메모 | uspto-grants-2007_12 |