Triethylamine → Z-Gln-Asp(OtBu)-Phe-OCH3

HRID 971542노트

반응식

HRID 971542 반응식
[NH2:1][C@H:2]([C:11]([NH:13][C@H:14]([C:22]([O:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:9])([CH3:8])[CH3:7].Cl.[CH:27]1[CH:32]=[CH:31][C:30]([CH2:33][O:34][C:35]([NH:37][C@H:38]([C:44](OC2C=CC([N+]([O-])=O)=CC=2)=[O:45])[CH2:39][CH2:40][C:41]([NH2:43])=[O:42])=[O:36])=[CH:29][CH:28]=1.C(N(CC)CC)C>CN(C)C=O>[NH:37]([C:35]([O:34][CH2:33][C:30]1[CH:31]=[CH:32][CH:27]=[CH:28][CH:29]=1)=[O:36])[C@H:38]([C:44]([NH:1][C@H:2]([C:11]([NH:13][C@H:14]([C:22]([O:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])=[O:45])[CH2:39][CH2:40][C:41](=[O:42])[NH2:43]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 111333Z-Gln-ONpHCID 131711563H-Asp(OtBu)-Phe-OCH3.HCl

생성물 1

HCID 131711562Z-Gln-Asp(OtBu)-Phe-OCH3

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

550 mg of H-Asp(OtBu)-Phe-OCH3.HCl together with 574 mg of Z-Gln-ONP are dissolved in 2.5 ml of absolute N,N-dimethylformamide and stirred with 0.20 ml of triethylamine for 15 hours at 30°-33° C. bath temperature. Thereafter the product is extracted by shaking with a large amount of ethyl acetate as described under 19 and the solution is dried and evaporated.

후처리

  1. extractionThereafter the product is extracted
  2. customthe solution is dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-f017a377cb684d529119602f821e0abc
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04159981

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