HCID 21313331, 화합물 → HCID 21313378, 화합물

HRID 971816노트

반응식

HRID 971816 반응식
[C:1]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([O:18]CC3C=CC=CC=3)=[CH:15][CH:16]=2)[C:11]([CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH:29]2[CH2:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:10]1[CH3:41])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>[Pd]>[C:1]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:11]([CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH:29]2[CH2:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:10]1[CH3:41])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 21313331HCID 21313331, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 21313378HCID 21313378, 화합물

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Catalytic reduction of the 1-benzoyl-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-benzyloxy-2-methylindole described above in Example 53 with hydrogen over a palladium-on-charcoal catalyst at about 50 pounds p.s.i.g. pressure affords 1-benzoyl-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-hydroxy-2-methylindole.

출처 및 근거

ORD 기록
ord-0830d9fd660547e2875c2262fc5bdcba
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04160862

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