Potassium Hydroxide → 2,2-Bis{4-[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]cyclohexyl}propane

HRID 972015

반응식

HRID 972015 반응식
[CH3:1][C:2]1([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11][C:4]2([NH:8][C:7](=[O:9])[NH:6][C:5]2=[O:10])[CH2:3]1.[O:17]1[CH2:41][CH:18]1[CH2:19][O:20][CH:21]1[CH2:26][CH2:25][CH:24]([C:27]([CH:30]2[CH2:35][CH2:34][CH:33]([O:36][CH2:37][CH:38]3[O:40][CH2:39]3)[CH2:32][CH2:31]2)([CH3:29])[CH3:28])[CH2:23][CH2:22]1.[OH-:42].[K+]>CO>[OH:17][CH:18]([CH2:41][N:6]1[C:5](=[O:42])[C:4]2([CH2:3][C:2]([CH3:1])([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]2)[NH:8][C:7]1=[O:9])[CH2:19][O:20][CH:21]1[CH2:22][CH2:23][CH:24]([C:27]([CH:30]2[CH2:31][CH2:32][CH:33]([O:36][CH2:37][CH:38]([OH:40])[CH2:39][N:6]3[C:5](=[O:10])[C:4]4([CH2:3][C:2]([CH3:16])([CH3:1])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]4)[NH:8][C:7]3=[O:9])[CH2:34][CH2:35]2)([CH3:29])[CH3:28])[CH2:25][CH2:26]1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 1145142,2'-((1-Methylethylidene)bis(cyclohexane-4,1-diyloxymethylene))bisoxiraneHCID 12680667,7,9,9-Tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

생성물 1

HCID 203967792,2-Bis{4-[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]cyclohexyl}propane

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

40.0 g of 7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, 17.5 g of 2,2-bis[4-(2,3-epoxypropoxy)cyclohexyl]propane and 2.0 g of potassium hydroxide were reacted in 300 ml of methanol, following substantially the same procedure as was described in Example 1. The desired Compound No. 118 was obtained in the form of a white powder, having an Rf value of 0.56 on thin-layer chromatography on silica gel using a 8:1:1:1 by volume mixture of ethyl acetate, benzene, ethanol and triethylamine as developing solvent.

출처 및 근거

ORD 기록
ord-365dedf39dcc46aca604c0a98528e130
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04162246

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