Methyl 2-methyl-3-(phenylmethoxy)propanoate → 3-Benzyloxy-2-methylpropan-1-ol

HRID 972058

반응식

HRID 972058 반응식
C[O:2][C:3](=O)[CH:4]([CH3:14])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[H-].COCCO[Al+]OCCOC.[Na+].[H-]>>[CH2:7]([O:6][CH2:5][CH:4]([CH3:14])[CH2:3][OH:2])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 13531536Methyl 2-methyl-3-(phenylmethoxy)propanoateHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

생성물 1

HCID 5622083-Benzyloxy-2-methylpropan-1-ol수율 90.5%

실험 절차

Reduction of the rac.-methyl-3-benzyloxy-2-methylpropionate was carried out with sodium bis(2-methoxyethoxy)-aluminum hydride using the procedure described in Example 9. Distillation of the crude product afforded the rac. 3-benzyloxy-2-methyl-1-propanol in 90.5% yield as a colorless liquid, b.p. 94°-98° C. (0.1 mm Hg.).

후처리

  1. distillationDistillation of the crude product

출처 및 근거

ORD 기록
ord-3913feb7270d49ddacc4e442f41d8b3f
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04163021

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