5-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione → 2-methyl-2,3-dihydro-1H-isoindol-5-amine

HRID 9723

반응식

HRID 9723 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[N:8]([CH3:11])[C:6](=O)[C:5]2=[CH:12][CH:13]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:11][N:8]1[CH2:9][C:4]2[C:5](=[CH:12][CH:13]=[C:2]([NH2:1])[CH:3]=2)[CH2:6]1

참가 물질

4

반응물 2

HCID 7269315-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dioneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 219881602-methyl-2,3-dihydro-1H-isoindol-5-amine수율 72%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2.643 g 4-Amino-N-methylphthalimide was suspended in 50 ml THF and added to 1.328 g lithium aluminum hydride in 50 ml THF at room temperature. The mixture was refluxed for 3 hrs, then stirred a further 3 days at room temperature. Excess LAH was destroyed by addition of water and the mixture filtered over celite. An aqueous phase was separated and extracted with CH2Cl2. The combined organic phases were dried and evaporated. The residue was stirred with HCl in MeOH and the evaporated to yield 1.6 g of the title compound as the hydrochlorid salt.

후처리

  1. temperatureThe mixture was refluxed for 3 hrs
  2. customExcess LAH was destroyed by addition of water
  3. filtrationthe mixture filtered over celite
  4. customAn aqueous phase was separated
  5. extractionextracted with CH2Cl2
  6. customThe combined organic phases were dried
  7. customevaporated
  8. stirringThe residue was stirred with HCl in MeOH
  9. customthe evaporated

출처 및 근거

ORD 기록
ord-a2cdac2f4a86442e912f0760f5d995ae
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091345B2

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