Formaldehyde → Sch-12679

HRID 972348노트

반응식

HRID 972348 반응식
[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[CH:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:8][NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1.[CH2:22]=O>C(O)=O>[CH3:1][O:2][C:3]1[C:19]([O:20][CH3:21])=[CH:18][C:6]2[CH:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:8][N:9]([CH3:22])[CH2:10][CH2:11][C:5]=2[CH:4]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 105409631H-3-Benzazepine, 2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-

생성물 1

HCID 5024Sch-12679

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A solution of 3.58 g. (0.0126 mol) of 7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine in 15 ml. of formic acid and 10 ml. of formaldehyde is refluxed for 18 hours. The reaction mixture is evaporated to dryness, 20 ml. of 6N hydrochloric acid is added and the solution is again evaporated to dryness to give a liquid. The latter is treated with 20 ml. of 10% sodium hydroxide solution and the mixture is extracted with ether. The dried extract is evaporated to give the liquid 7,8-dimethoxy-3-methyl-1-phenyl-2,3,4,5- tetrahydro-1H-3-benzazepine.

후처리

  1. customThe reaction mixture is evaporated to dryness, 20 ml
  2. additionof 6N hydrochloric acid is added
  3. customthe solution is again evaporated to dryness
  4. customto give a liquid
  5. additionThe latter is treated with 20 ml
  6. extractionof 10% sodium hydroxide solution and the mixture is extracted with ether
  7. extractionThe dried extract
  8. customis evaporated

출처 및 근거

ORD 기록
ord-97c0d6969e624b6d9ab17a7b0eca9b6c
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04052506

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