(2-Isothiocyanatoethyl)dimethylamine → N-(2-Dimethylaminoethyl)-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][N:16]=[C:17]=[S:18]>>[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][NH:16][C:17]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[S:18]

참가 물질

반응물 2

HCID 3853726(2-Isothiocyanatoethyl)dimethylamine

HCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

생성물 1

HCID 20557883N-(2-Dimethylaminoethyl)-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea

실험 절차

Treating N-(2-pyrimidylmethyl)ethylenediamine with 2-dimethylaminoethyl isothiocyanate, then concentrating and separating by column chromatography by the procedure of Example 40(a)(ii) gives the title compound.

후처리

concentrationconcentrating
customseparating by column chromatography by the procedure of Example 40(a)(ii)

출처 및 근거

ORD 기록: ord-2b5d19c593ea4647a221e1126553ef87
출처 데이터셋: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04053473

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