Ethanol → Benzene, 1,3-dichloro-5-nitro-

HRID 972665

반응식

HRID 972665 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([Cl:12])[C:3]=1N.C(O)C.N([O-])=O.[Na+].S(=O)(=O)(O)O>O>[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([Cl:12])[CH:3]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 74302,6-Dichloro-4-nitroanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 12064Benzene, 1,3-dichloro-5-nitro-수율 84%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Amer. Chem. Soc., 72 (1950), 798, discloses that 2,6-dichloro-4-nitroaniline, ethanol and sodium nitrite can be reacted at the boil, in the absence of water and in the presence of concentrated sulfuric acid, to give 3,5-dichloronitrobenzene in a yield of 84%. A corresponding reaction to give the 3,5-dibromo derivative gives a yield of 91%. The process is unsatisfactory in respect of yield and purity of the end product and simple, reliable and economical operation, especially on an industrial scale.

출처 및 근거

ORD 기록
ord-64167b01dbd041b19e0a44155c074f12
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053527

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