Sulfuric Acid → 1,3-dibromo-5-nitrobenzene

HRID 972668노트

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HRID 972668 반응식
[Br:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([Br:12])[C:3]=1N.C(O)(C)C.S(=O)(=O)(O)O.N([O-])=O.[Na+]>O>[Br:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([Br:12])[CH:3]=1

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 132312,6-Dibromo-4-nitroanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 2387111,3-dibromo-5-nitrobenzene수율 99%

시약·촉매·용매 1

HCID 962Water용매3회

실험 절차

296 parts of 2,6-dibromo-4-nitro-aniline are introduced into 400 parts of isopropanol and 750 parts of water and 130 parts of concentrated sulfuric acid (98 percent strength by weight) are then added to the mixture. A solution of 105 parts of NaNO2 in 150 parts of water is run in at 70° C. as described in Example 1. The mixture is cooled, 300 parts of water are added and the product is filtered off. 278 parts of 3,5-dibromo-nitro-benzene (99% of theory), of melting point 102°-104° C., are obtained.

후처리

  1. additionare then added to the mixture
  2. customis run in at 70° C.
  3. temperatureThe mixture is cooled
  4. filtrationthe product is filtered off

출처 및 근거

ORD 기록
ord-0b82c481134d4f60ab1fedac893bed63
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053527

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