Sulfuric Acid → 1-Chloro-3-nitrobenzene

HRID 972671

반응식

HRID 972671 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1N.C(O)(C)C.S(=O)(=O)(O)O.N([O-])=O.[Na+]>O>[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][CH:3]=1

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 84922-Chloro-4-nitroanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 84891-Chloro-3-nitrobenzene수율 90%

시약·촉매·용매 1

HCID 962Water용매3회

실험 절차

172.5 parts of 2-chloro-4-nitro-aniline are introduced into 180 parts of isopropanol and 300 parts of water, and 200 parts of concentrated sulfuric acid (98 percent strength by weight) are then added to the mixture. A solution of 125 parts of NaNO2 in 175 parts of water is run in at 50° C., as described in Example 1. The mixture is cooled, 400 parts of water are added and the product is filtered off. 142 parts (90% of theory) of 3-chloro-nitro-benzene, of melting point 40°-42° C., are obtained.

후처리

  1. additionare then added to the mixture
  2. customis run in at 50° C.
  3. temperatureThe mixture is cooled
  4. filtrationthe product is filtered off

출처 및 근거

ORD 기록
ord-bb2327d0a7014402a0420096593a1132
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053527

연결된 노트

불러오는 중…