Sulfuric Acid → 1-Chloro-3-nitrobenzene
반응식
[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1N.C(O)(C)C.S(=O)(=O)(O)O.N([O-])=O.[Na+]>O>[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][CH:3]=1참가 물질
6
실험 절차
172.5 parts of 2-chloro-4-nitro-aniline are introduced into 180 parts of isopropanol and 300 parts of water, and 200 parts of concentrated sulfuric acid (98 percent strength by weight) are then added to the mixture. A solution of 125 parts of NaNO2 in 175 parts of water is run in at 50° C., as described in Example 1. The mixture is cooled, 400 parts of water are added and the product is filtered off. 142 parts (90% of theory) of 3-chloro-nitro-benzene, of melting point 40°-42° C., are obtained.
후처리
- additionare then added to the mixture
- customis run in at 50° C.
- temperatureThe mixture is cooled
- filtrationthe product is filtered off
출처 및 근거
- ORD 기록
- ord-bb2327d0a7014402a0420096593a1132
- 출처 데이터셋
- uspto-grants-1977_10
- 특허 번호
- US04053527
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