3-Methyl-2-butanone → HCID 21443884, 화합물

HRID 972709

반응식

HRID 972709 반응식
[CH:1]([C:4]([CH3:6])=[O:5])([CH3:3])[CH3:2].Cl[CH:8]([Cl:16])[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>O1CCCC1>[Cl:16][C:8]1([O:5][C:4]1([CH:1]([CH3:3])[CH3:2])[CH3:6])[C:9]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:10]

참가 물질

4

반응물 2

HCID 112513-Methyl-2-butanoneHCID 30164831,1-Dimethylethyl dichloroacetate

생성물 1

HCID 21443884HCID 21443884, 화합물수율 98.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 122 g of potassium tert.-butylate in 720 ml of tetrahydrofuran was added at -20° C. with stirring under an inert atmosphere to a mixture of 95 g of methyl isopropyl ketone and 185 g of tert.butyl dichloroacetate and after returning the temperature to room temperature, the mixture was stirred for 2 hours. The mixture was poured into ice water and the mixture was stirred and the organic phase was separated. The organic phase was washed with aqueous sodium chloride solution, dried over magnesium sulfate, passed through vegetable charcoal and concentrated to dryness to obtain 230.4 g of tert.butyl 2-chloro-2,3-epoxy-3-isopropyl-butanoate.

후처리

  1. customto room temperature
  2. stirringthe mixture was stirred
  3. customthe organic phase was separated
  4. washThe organic phase was washed with aqueous sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-d9affb2b65f3455eaf12a6d03e58495f
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04053597

연결된 노트

불러오는 중…