Thionyl Chloride → 2-Methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine hydrochloride
반응식
[ClH:1].[CH3:2][C:3]1[C:8]([OH:9])=[C:7]([CH2:10]O)[C:6]([CH:12]=[CH2:13])=[CH:5][N:4]=1.S(Cl)([Cl:16])=O>O1CCCC1>[ClH:16].[CH3:2][C:3]1[C:8]([OH:9])=[C:7]([CH2:10][Cl:1])[C:6]([CH:12]=[CH2:13])=[CH:5][N:4]=1참가 물질
4
실험 절차
A mixture of 1.65 g. of 2-methyl-3hydroxy-4-hydroxymethyl-5vinylpyridine hydrochloride, 1 ml. of thionyl chloride and 20 ml. of tetrahydrofuran is refluxed 6 hours. After cooling, the precipitate is collected on a filter, washed with ether and dried to give 2-methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine hydrochloride.
후처리
- additionA mixture of 1.65 g
- temperatureAfter cooling
- customthe precipitate is collected on a filter
- washwashed with ether
- customdried
출처 및 근거
- ORD 기록
- ord-960be41802f1491ab5888b47538defeb
- 출처 데이터셋
- uspto-grants-1977_10
- 특허 번호
- US04053606
반응 노트
불러오는 중…