Phosgene → 5-Trifluoromethylbenzothiazol-2-yl isocyanate

HRID 972935노트

반응식

HRID 972935 반응식
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=2[N:10]=1>C(OCC)(=O)C>[F:18][C:15]([F:16])([F:17])[C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([N:5]=[C:1]=[O:2])=[N:10][C:9]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 70186255-(Trifluoromethyl)-1,3-benzothiazol-2-amine

생성물 1

HCID 544616495-Trifluoromethylbenzothiazol-2-yl isocyanate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A saturated solution of phosgene in ethyl acetate (200 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Amino-5-trifluoromethylbenzothiazole (0.1 mole) is added with stirring. After the addition is completed, the reaction mixture is heated at reflux for a period of about one hour. After this time the mixture is cooled, and the solid product formed is recovered by filtration. The solid is then dried to yield the desired product 5-trifluoromethylbenzothiazol2-yl isocyanate dimer.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. additionAfter the addition
  4. temperaturethe reaction mixture is heated
  5. temperatureat reflux for a period of about one hour
  6. temperatureAfter this time the mixture is cooled
  7. customthe solid product formed
  8. filtrationis recovered by filtration
  9. customThe solid is then dried

출처 및 근거

ORD 기록
ord-f8ea6c611eac4f6d89aca59a91380c17
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04054574

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