Isopropylamine → HCID 21400882, 화합물

HRID 973118

반응식

HRID 973118 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4](Cl)[N:3]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>>[CH:13]([NH:16][C:2]1[N:7]=[C:6]([NH:16][CH:13]([CH3:15])[CH3:14])[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([NH:9][CH:5]([CH3:6])[CH3:4])[N:3]=1)([CH3:15])[CH3:14]

참가 물질

3

반응물 2

HCID 6363IsopropylamineHCID 42978432,4,6-Trichloro-5-nitropyrimidine

생성물 1

HCID 21400882HCID 21400882, 화합물수율 148.5%

실험 절차

1.15 g (0.005 mol) of 2,4,6-trichloro-5-nitropyrimidine are dissolved in 50 ml of alcohol and the solution is then treated with 2.9 g (0.05 mol) of isopropylamine. The mixture is stirred for 3 hours at room temperature after the temperature has first risen to 35° C, and then it is evaporated. The residue is treated with 100 ml of water and extracted twice with ether. The ethereal extract is dried over MgSO4 for 4 hours, filtered, and evaporated, to yield 1.1 g of 2,4,6-tri-isopropylamino-5-nitro-pyrimidine as an oil; b.p. 185° C at 0.001 Torr.

후처리

  1. customhas first risen to 35° C
  2. customit is evaporated
  3. additionThe residue is treated with 100 ml of water
  4. extractionextracted twice with ether
  5. extractionThe ethereal extract
  6. dry with materialis dried over MgSO4 for 4 hours
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-5cf90ab457424d57ae75bf41018b553b
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04055411

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