Ethylamine → HCID 68122832, 화합물

HRID 973121노트

반응식

HRID 973121 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.C([N:18]([CH2:21][CH3:22])CC)C.[CH2:23]([NH2:25])[CH3:24]>C(O)C>[CH2:23]([NH:25][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH:18][CH2:21][CH3:22])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1)[CH3:24]

참가 물질

5

반응물 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 214008694,6-Dichloro-5-nitro-2-(trifluoromethyl)pyrimidine

생성물 1

HCID 68122832HCID 68122832, 화합물수율 98.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5.25 g (0.02 mol) of 4,6-dichloro-5-nitro-2-trifluoromethyl-pyrimidine (J. Org. Chem. 26 (1961), pp. 4504-8) are dissolved in 150 ml of abs. ethanol. The solution is treated with 5 ml of triethylamine (0.05 mol) and 4.5 g (0.1 mol) of ethylamine and the mixture is stirred overnight, then evaporated to dryness. The residue is taken up in ether and washed with water. The ethereal phase is dried and concentrated to yield 5.5 g of 4,6-bis-ethylamino-5-nitro-2-trifluoromethyl-pyrimidine; m.p. 60°-65° C.

후처리

  1. dissolution4504-8) are dissolved in 150 ml of abs
  2. customevaporated to dryness
  3. washwashed with water
  4. customThe ethereal phase is dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4d8667de238e48dc9ca1cb45d690dc9e
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04055411

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