Ammonia → 2,4,6-Triphenylpyridine

HRID 973184

반응식

HRID 973184 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[NH3:18]>C(O)(=O)C>[C:11]1([C:10]2[CH:2]=[C:1]([C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH:2]=[C:1]([C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:18]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 240BenzaldehydeHCID 7410Acetophenone

생성물 1

HCID 1363702,4,6-Triphenylpyridine수율 68%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

"Simple aldehydes and ketones without activating groups require mildly forcing conditions and produce the fully aromatic pyridines; accordingly, acetophenone, benzaldehyde, and ammonia in refluxing acetic acid gave a 68% yield of 2,4,6,-triphenylpyridine and a 25% yield of β-phenylpropionophenone."

출처 및 근거

ORD 기록
ord-aa7d96fb12664a28b4538204f2d3b683
출처 데이터셋
uspto-grants-1977_10
특허 번호
US04055588

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