Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 19-Hydroxy-17beta(1-oxopropoxy)androst-4-en-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 17beta,19-Bis(1-oxopropoxy)-androst-4-en-3-one | HCID 54342612 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 19-Hydroxy-17beta(1-oxopropoxy)androst-4-en-3-one | HCID 54223287 | — |
반응 단계
A solution of 11 g of 17β,19-bis(1-oxopropoxy)androst-4-en-3-one in 2 liters of methanol is treated with 2.5 g of sodium carbonate in 250 ml of water and refluxed for one hour after which the reaction mixture is poured into 10 liters of water, and the solid collected by filtration. The solid is dissolved in methylene chloride, dried over magnesium sulfate, filtered and the solvent removed. The residue is crystallized from acetone-hexane yielding 6 g of 19-hydroxy-17β(1-oxopropoxy)androst-4-en-3-one. M.P. 160°-162° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04055641 |
| 출처 데이터셋 | uspto-grants-1977_10 |
| ORD ID | ord-bab77e73d7be4d24aa386cacbeb4ff0f |
| 출처 메모 | uspto-grants-1977_10 |