Chloroacetyl chloride → 11-[(2-Chloroacetyl)amino]undecanoic acid
반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13].[Cl:15][CH2:16][C:17](Cl)=[O:18]>C(OCC)(=O)C>[Cl:15][CH2:16][C:17]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:18]참가 물질
4
실험 절차
11-Aminoundecanoic acid (10.7 grams; 0.05 mole) was added to 125 ml of ethyl acetate and refluxed with 5 ml of chloroacetyl chloride as above. After one hour no precipitate was noted and the excess chloroacetyl chloride and ethyl acetate was removed by vacuum distillation. 14 Grams (96% yield) of N-chloroacetylamino-11-undecanoic acid was obtained. This compound was confirmed by elemental analysis and infrared spectroscopy.
후처리
- customthe excess chloroacetyl chloride and ethyl acetate was removed by vacuum distillation
출처 및 근거
- ORD 기록
- ord-dfc2044f77d94a679c3a98792581ed1c
- 출처 데이터셋
- uspto-grants-1977_10
- 특허 번호
- US04055663
반응 노트
불러오는 중…