HCID 12850094, 화합물 → HCID 12850095, 화합물
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9]Br)=[CH:4][C:3]=1[S:12][CH3:13].[B-].[Na+]>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[O:11][CH2:9]2)=[CH:4][C:3]=1[S:12][CH3:13]참가 물질
4
실험 절차
To a mixture of 18 g of 4'-methyl-3'-methylthio-2-bromoacetophenone and 300 ml of methanol was gradually added 8 g of sodium borohydrate and thereafter the mixture was stirred for one hour at 40°-50° C. After distilling off methanol from the reaction mixture, 200 ml of water was added to the residue and the product was extracted with 300 ml of benzene. Then, benzene was distilled off and the residue formed was purified by a silica gel column chromatography (eluant: benzene) to provide 8.5 g of oily 4-methyl-3-methylthiostyrene oxide.
후처리
- distillationAfter distilling off methanol from the reaction mixture, 200 ml of water
- additionwas added to the residue
- extractionthe product was extracted with 300 ml of benzene
- distillationThen, benzene was distilled off
- customthe residue formed
- customwas purified by a silica gel column chromatography (eluant: benzene)
출처 및 근거
- ORD 기록
- ord-8484c7a13fab494f9f08f56e09cfae44
- 출처 데이터셋
- uspto-grants-1991_11
- 특허 번호
- US05063246
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