O-Toluidine → HCID 10332347, 화합물
반응식
[NH2:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][C:14]1[C:15]([CH3:20])=[CH:16][CH:17]=[CH:18][CH:19]=1>C(O)C>[NH2:1][C:2]1[N:11]=[C:10]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1참가 물질
4
실험 절차
2-Amino-4-chloroquinazoline (0.64 g, 0.0036 mol) was heated to 170° in o-toluidine (1 ml, 0.008 mol) for 1 hour. The reaction mixture was dissolved in ethanol, stripped and partitioned between chloroform and NaOH solution (pH 9). The organic solution was dried, filtered and excess solvent removed to give an oil which afforded crystals of 2-amino-4-(2-methylphenylamino)-quinazoline (0.55 g, 62%) m.p. 273°-275° (from ethanol).
후처리
- custompartitioned between chloroform and NaOH solution (pH 9)
- customThe organic solution was dried
- filtrationfiltered
- customexcess solvent removed
- customto give an oil which
출처 및 근거
- ORD 기록
- ord-fe260666ec40421e802a18037708db9a
- 출처 데이터셋
- uspto-grants-1991_11
- 특허 번호
- US05064833
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