N-Methylaniline → HCID 67925967, 화합물

HRID 973581노트

반응식

HRID 973581 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[CH3:20])[N:3]=1.[CH3:21][NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[ClH:1].[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:4]2[N:3]=[C:2]([N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH3:21])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[C:14]([CH3:20])[CH:15]=1

참가 물질

3

반응물 2

HCID 7515N-MethylanilineHCID 10267004HCID 10267004, 화합물

생성물 1

HCID 67925967HCID 67925967, 화합물수율 12.6%

실험 절차

Substituting 4-chloro-2-[(4-chloro-2-methylphenyl)amino]quinazoline (1.0 g) and N-methylaniline (1.0 g) for the reagents in Example 33C and using analogous conditions and work-up gave the title compound (0.17 g), m.p. 263°-265°, after two recrystallisations from ethanol/diethyl ether.

출처 및 근거

ORD 기록
ord-58350b9c9a214b24a9dd94cc2dfb939b
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064833

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