Benzyl (3-Oxopropyl)carbamate → HCID 10450970, 화합물

HRID 973632노트

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HRID 973632 반응식
[CH2:1]([PH:5](=[O:9])[O:6][CH2:7][CH3:8])[CH2:2][CH2:3][CH3:4].[CH2:10]([O:17][C:18]([NH:20][CH2:21][CH2:22][CH:23]=[O:24])=[O:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(N(CC)CC)C>[CH2:10]([O:17][C:18]([NH:20][CH2:21][CH2:22][CH:23]([P:5]([CH2:1][CH2:2][CH2:3][CH3:4])(=[O:9])[O:6][CH2:7][CH3:8])[OH:24])=[O:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 10398106Benzyl (3-Oxopropyl)carbamateHCID 178454912HCID 178454912, 화합물

생성물 1

HCID 10450970HCID 10450970, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
100 °C

실험 절차

A mixture of 1.50 g of ethyl (n-butyl)phosphinate, 1.01 g of triethylamine and 2.07 g 3-(N-benzyloxycarbonylamino)propionaldehyde is heated to 100° C. for 4 hours. After this time the mixture is cooled to 20° and the volatile components are removed in high vacuum. Chromatography of the residue on silica gel affords ethyl 3-(N-benzyloxycarbonylamino)-1-hydroxy-propyl(n-butyl)phosphinate as a viscous oil.

후처리

  1. temperatureAfter this time the mixture is cooled to 20°
  2. customthe volatile components are removed in high vacuum

출처 및 근거

ORD 기록
ord-e5060a58d1324f68ab5c8ab9b5f84573
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064819

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