HCID 19090869, 화합물 → HCID 19090888, 화합물

HRID 973646노트

반응식

HRID 973646 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:20]([PH:24](=[O:28])[O:25][CH2:26][CH3:27])[CH2:21][CH2:22][CH3:23]>C(N(CC)CC)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]([P:24]([CH2:20][CH2:21][CH2:22][CH3:23])(=[O:28])[O:25][CH2:26][CH3:27])[OH:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 19090869HCID 19090869, 화합물HCID 178454912HCID 178454912, 화합물

생성물 1

HCID 19090888HCID 19090888, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A material of 283 mg of 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-propionaldehyde, 150 mg of ethyl n-butyl-phosphinate and 101 mg of triethylamine is heated to 100° C. for 21/2 hours. The mixture is cooled to room temperature and the volatile components are removed in high vacuum. Chromatography of the residue on silica-gel affords ethyl 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-1-hydroxy-propyl-(n-butyl)phosphinate.

후처리

  1. customthe volatile components are removed in high vacuum

출처 및 근거

ORD 기록
ord-fe88af4ee82341e1906204a1cb20ce45
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064819

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