Dimethylformamide → (1-3-Chlorophenyl)-3-(1H-1,2,4-Triazol-1-ylmethyl)-2(1H)-Quinolone

HRID 973654노트

반응식

HRID 973654 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]([CH2:18]Cl)[C:9]2=[O:20])[CH:5]=[CH:6][CH:7]=1.N1C=[CH:24][N:23]=[N:22]1.[Na].[CH3:27][N:28](C)C=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]([CH2:18][N:23]3[CH:24]=[N:28][CH:27]=[N:22]3)[C:9]2=[O:20])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 190216441-(3-chlorophenyl)-3-chloromethyl-2(1H)-quinoloneHCID 178507080HCID 178507080, 화합물

생성물 1

HCID 19021633(1-3-Chlorophenyl)-3-(1H-1,2,4-Triazol-1-ylmethyl)-2(1H)-Quinolone

실험 절차

Following the procedure of example 22, react 1-(3-chlorophenyl)-3-chloromethyl-2(1H)-quinolone with sodium triazole in dimethylformamide. Chromatograph to obtain the major product, 1-(3-Chlorophenyl)-3-(1H-1,2,4-Triazol-1-ylmethyl)-2(1H)-Quinolone.

출처 및 근거

ORD 기록
ord-58f3621c84c346d38be49759df5b8108
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064837

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