Ammonia → 2-(2,6-dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazole-4-carboxamide

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[N:17]=[C:16]([C:18](O)=[O:19])[CH:15]=[N:14]1.S(Cl)(Cl)=O.[NH3:25]>O1CCCC1>[Cl:12][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=[C:2]([Cl:1])[C:3]=1[N:13]1[N:17]=[C:16]([C:18]([NH2:25])=[O:19])[CH:15]=[N:14]1

참가 물질

실험 절차

2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazole-4-carboxylic acid (8.18 g) was treated with thionyl chloride (150 ml) to give crude acid chloride. A solution of this in tetrahydrofuran was added to ammonia with ice cooling. The mixture was stirred at room temperature for one hour, solvent was removed and the product extracted with ethyl acetate and worked up in conventional manner to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazole-4-carboxamide, m.p. 239° (Compound 14 ).