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(2S,3S)-2-Chloro-3-methylvaleric Acid → p-[5-(2,6-Dimethylheptyl)-pyrimidin-2-yl]-phenyl (S,S)-3-methyl-2-chloropentanoate

HRID 973711
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인쇄 미리보기

반응식

HRID 973711 반응식
[CH3:1][C@@H:2]([CH2:8][CH3:9])[C@H:3]([Cl:7])[C:4]([OH:6])=[O:5].[CH3:10][CH:11]([CH2:26][CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:12][C:13]1[CH:14]=[N:15][C:16]([C:19]2[CH:24]=[CH:23][C:22](O)=[CH:21][CH:20]=2)=[N:17][CH:18]=1.C(OC(OCC)C(C[C@@H](C)CCCC(C)C)C(OCC)OCC)C>C(Cl)Cl>[CH3:1][C@@H:2]([CH2:8][CH3:9])[C@H:3]([Cl:7])[C:4]([O:6][C:22]1[CH:21]=[CH:20][C:19]([C:16]2[N:15]=[CH:14][C:13]([CH2:12][CH:11]([CH3:10])[CH2:26][CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:18][N:17]=2)=[CH:24][CH:23]=1)=[O:5]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11051847(2S,3S)-2-Chloro-3-methylvaleric AcidHCID 53766363(S)-1,1,3,3-tetraethoxy-2-(2,6-dimethylheptyl)-propaneHCID 136125432p-[5--(2,6-Dimethylheptyl)-pyrimidin-2-yl]phenol

생성물 1

HCID 57237993p-[5-(2,6-Dimethylheptyl)-pyrimidin-2-yl]-phenyl (S,S)-3-methyl-2-chloropentanoate

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

실험 절차

A mixture of 8 g of (S,S)-3-methyl-2-chloropentanoic acid, 16 g of optically active p-[5--(2,6-dimethylheptyl)-pyrimidin-2-yl]phenol [obtainable by condensation, known from the literature, of (S)-1,1,3,3-tetraethoxy-2-(2,6-dimethylheptyl)-propane with 4-hydroxyphenylamidine hydrochloride], 11.6 g of N,N-dicyclohexylcarbodiimide, 0.6 g of 4-N,N-dimethylaminopyridine and 300 ml of methylene chloride is stirred overnight at room temperature. After the urea derivative which has precipitated has been filtered off, the filtrate is washed with dilute hydrochloric acid and H2O and the organic phase is worked up in the customary manner. p-[5-(2,6-Dimethylheptyl)-pyrimidin-2-yl]-phenyl (S,S)-3-methyl-2-chloropentanoate is obtained.

후처리

  1. customobtainable by condensation
  2. customAfter the urea derivative which has precipitated
  3. filtrationhas been filtered off
  4. washthe filtrate is washed with dilute hydrochloric acid and H2O

출처 및 근거

ORD 기록
ord-5bcee076aaf44e0693936ec57a8aa534
출처 데이터셋
uspto-grants-1991_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05064569

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