p-Toluenesulfonic acid → Ethyl 5,5,5-trifluoro-4-oxopentanoate

HRID 973746노트

반응식

HRID 973746 반응식
[F:1][C:2]([F:18])([F:17])[C:3](=[O:16])[CH:4](C(OCC)=O)[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].B(O)(O)O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[F:1][C:2]([F:17])([F:18])[C:3](=[O:16])[CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

4

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 7628Boric AcidHCID 11346247Butanedioic acid, (trifluoroacetyl)-, diethyl ester

생성물 1

HCID 13379932Ethyl 5,5,5-trifluoro-4-oxopentanoate수율 32.7%

실험 절차

45 g of the product of Step A, 10.3 g of boric acid and 1 g of p-toluenesulfonic acid were heated at 180° C. for 3 hours and the mixture was poured into ice and extracted with ethyl acetate. The mixture was decanted, dried and concentrated under reduced pressure and the residue was distilled to obtain 10.8 g of expected product.

후처리

  1. additionthe mixture was poured into ice
  2. extractionextracted with ethyl acetate
  3. customThe mixture was decanted
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. distillationthe residue was distilled

출처 및 근거

ORD 기록
ord-83ba7ad84df644098a26a657708b16de
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05064861

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