Dicyclohexylcarbodiimide → HCID 131715158, 화합물

HRID 973901노트

반응식

HRID 973901 반응식
C1(N=C=NC2CCCCC2)CCCCC1.[NH2:16][CH2:17][CH2:18][C:19]1[NH:28][C:27]2[C:26](=[O:29])[N:24]([CH3:25])[C:23](=[O:30])[N:22]([CH3:31])[C:21]=2[N:20]=1.[CH:32]1[C:37]([C:38]([OH:40])=[O:39])=[CH:36][C:35]2[C:41]3([O:57][C:58](=[O:59])[C:34]=2[CH:33]=1)[C:51]1[CH:52]=[CH:53][C:54]([OH:56])=[CH:55][C:50]=1[O:49][C:43]1[CH:44]=[C:45]([OH:48])[CH:46]=[CH:47][C:42]3=1>N1C=CC=CC=1>[NH2:16][CH2:17][CH2:18][C:19]1[NH:28][C:27]2[C:26](=[O:29])[N:24]([CH3:25])[C:23](=[O:30])[N:22]([CH3:31])[C:21]=2[N:20]=1.[CH:32]1[C:37]([C:38]([OH:40])=[O:39])=[CH:36][C:35]2[C:41]3([O:57][C:58](=[O:59])[C:34]=2[CH:33]=1)[C:51]1[CH:52]=[CH:53][C:54]([OH:56])=[CH:55][C:50]=1[O:49][C:43]1[CH:44]=[C:45]([OH:48])[CH:46]=[CH:47][C:42]3=1

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 768066-CarboxyfluoresceinHCID 4140301AC1N56UX

생성물 1

HCID 131715158HCID 131715158, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

N,N'-dicyclohexylcarbodiimide (15 mg) was added to a solution of 8-β-aminoethyltheophylline (5 mg) and carboxyfluorescein (5 mg) in 0.5 ml of pyridine. The reaction was allowed to proceed for two hours at room temperature and the reaction product was purified twice employing silica gel thin-layer chromatography using a thin chloroform:methanol (2:1) mixture as developing solvent to yield an 8-β-amino ethyltheophylline-carboxyfluorescein conjugate of the formula: ##STR10##

후처리

  1. customthe reaction product was purified twice employing silica gel thin-layer chromatography

출처 및 근거

ORD 기록
ord-d7912e197081430b82dbad2178b728a4
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05066426

반응 노트

불러오는 중…