Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-3(2H)-pyridazinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 4H-pyran-4-one | HCID 7968 | — |
| 반응물 | 6-(4-aminophenyl)-3(2H)-pyridazinone hydrochloride | HCID 12196573 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-3(2H)-pyridazinone | HCID 19794224 | — |
반응 단계
A stirred mixture of 6-(4-aminophenyl)-3(2H) -pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.71 g), and water (20 ml), was heated under reflux for 2 hours. The pH of the hot solution was adjusted to 8 with aqueous ammonia and the mixture was cooled to give the crude product, 1.84 g, m.p. 338-340° C. Recrystallisation from aqueous ethanol gave the title compound, 1,4 g, m.p. 339-341° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05066653 |
| 출처 데이터셋 | uspto-grants-1991_11 |
| ORD ID | ord-3da135e2b7984687b0a2e0051f53dee3 |
| 출처 메모 | uspto-grants-1991_11 |