Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-3(2H)-pyridazinone

HRID 973930

반응식

HRID 973930 반응식
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12](=[O:15])[NH:13][N:14]=2)=[CH:5][CH:4]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.N>O>[O:22]=[C:19]1[CH:20]=[CH:21][N:2]([C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH:10]=[CH:11][C:12](=[O:15])[NH:13][N:14]=3)=[CH:5][CH:4]=2)[CH:17]=[CH:18]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 79684H-pyran-4-oneHCID 121965736-(4-aminophenyl)-3(2H)-pyridazinone hydrochloride

생성물 1

HCID 197942246-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-3(2H)-pyridazinone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A stirred mixture of 6-(4-aminophenyl)-3(2H) -pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.71 g), and water (20 ml), was heated under reflux for 2 hours. The pH of the hot solution was adjusted to 8 with aqueous ammonia and the mixture was cooled to give the crude product, 1.84 g, m.p. 338-340° C. Recrystallisation from aqueous ethanol gave the title compound, 1,4 g, m.p. 339-341° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. temperaturethe mixture was cooled
  4. customto give the crude product, 1.84 g, m.p. 338-340° C
  5. customRecrystallisation from aqueous ethanol

출처 및 근거

ORD 기록
ord-3da135e2b7984687b0a2e0051f53dee3
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05066653

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