N,N-diethyl-2-butyne-1,4-diamine → N-(4-diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride

HRID 973991노트

반응식

HRID 973991 반응식
[CH2:1]([N:3]([CH2:9][CH3:10])[CH2:4][C:5]#[C:6][CH2:7][NH2:8])[CH3:2].[Cl:11][C:12]([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13](Cl)=[O:14]>C1C=CC=CC=1>[ClH:11].[CH2:1]([N:3]([CH2:9][CH3:10])[CH2:4][C:5]#[C:6][CH2:7][NH:8][C:13](=[O:14])[C:12]([Cl:11])([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 12259571N,N-diethyl-2-butyne-1,4-diamineHCID 197755142-Chloro-2-cyclohexyl-2-phenylacetyl chloride

생성물 1

HCID 19775490N-(4-diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride수율 92.8%

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

A solution of 4-diethylamino-2-butynylamine (0.14 g) in benzene (2.5 ml) was added dropwise to a solution of 2-chloro-2-cyclohexyl-2-phenylacetyl chloride (0.27 g) in benzene (2.5 ml below 25° C. After being stirred at room temperature for 19.5 hours, the resulting precipitates were collected by filtration and recrystallized from a mixture of acetone and diethyl ether to give N-(4-diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride (0.19 g).

후처리

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. customrecrystallized from a mixture of acetone and diethyl ether

출처 및 근거

ORD 기록
ord-ab64516c28dc481783cc8c7ef0788c98
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05066680

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