Malonic Acid → 3-(4-Phenylphenyl)prop-2-enoic acid

HRID 974021

반응식

HRID 974021 반응식
[C:1]1([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(=O)[CH2:16][C:17]([OH:19])=[O:18].N1CCCCC1>N1C=CC=CC=1>[C:1]1([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=[CH:16][C:17]([OH:19])=[O:18])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 76689(1,1'-Biphenyl)-4-carboxaldehyde

생성물 1

HCID 254923-(4-Phenylphenyl)prop-2-enoic acid수율 76.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 4-phenylbenzaldehyde (5.17 g, 28.4 mmol), malonic acid (4.0 g), pyridine (20 ml), and piperidine (0.5 ml) was heated until gas evolution began. Heating was continued until gas evolution ceased (about 30 minutes at 90°-100° C.). The mixture was cooled, and the solid product triturated with boiling methanol (150 ml) and enough concentrated HCl to make the mixture acidic. The mixture was cooled, and the product collected by filtration, washed with water and methanol, and dried in vacuo to provide 4-phenylcinnamic acid (4.85 g, 76% yield), mp 220°-225° C. This material was dissolved in ethanol (150 ml) containing concentrated sulfuric acid (0.5 ml) and triethyl orthoacetate (3.5 ml), and refluxed for 24 hours. Removal of the solvent and recrystallization of the residue from methanol-water provided the ethyl ester (5.0 g, 92% yield), mp 88°-89° C.

후처리

  1. temperaturewas heated until gas evolution
  2. temperatureHeating
  3. custom(about 30 minutes at 90°-100° C.)
  4. temperatureThe mixture was cooled
  5. customthe solid product triturated with boiling methanol (150 ml) and enough concentrated HCl
  6. temperatureThe mixture was cooled
  7. filtrationthe product collected by filtration
  8. washwashed with water and methanol
  9. customdried in vacuo

출처 및 근거

ORD 기록
ord-e3f377d3f72849ed9be058409a8f0fd8
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05066658

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