N-(2-fluoro-4-nitrophenyl)acetamide → n-(4-Amino-2-fluorophenyl)acetamide

HRID 974142노트

반응식

HRID 974142 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[F:14])(=[O:3])[CH3:2]>[Pd].CO>[NH2:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[C:6]([F:14])[CH:7]=1

참가 물질

4

반응물 1

HCID 3412310N-(2-fluoro-4-nitrophenyl)acetamide

생성물 1

HCID 255648n-(4-Amino-2-fluorophenyl)acetamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet.

후처리

  1. additionare added
  2. customis carried out in the course of 4 hours at 50° C. under a hydrogen
  3. customAfter the catalyst has been removed
  4. distillation450 ml of methanol are distilled off from the reaction solution in vacuo
  5. customthe product which has precipitated
  6. filtrationis filtered off with suction
  7. washthe residue is washed with a little methanol
  8. customdried at 50°-60° C. in a vacuum cabinet

출처 및 근거

ORD 기록
ord-40574bfebfd848c6a0340bf2ca154c17
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05067967

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