Benzene, 1-bromo-4-(trifluoromethyl)- → HCID 178444406, 화합물

HRID 974159노트

반응식

HRID 974159 반응식
[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]#[CH:13])[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:21]=[CH:20][C:19](Br)=[CH:18][CH:17]=1>[Cu]I.C(N(CC)CC)C>[CH2:1]([C@H:6]1[CH2:7][CH2:8][C@H:9]([C:12]#[C:13][C:19]2[CH:20]=[CH:21][C:16]([C:15]([F:24])([F:23])[F:14])=[CH:17][CH:18]=2)[CH2:10][CH2:11]1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 178455744HCID 178455744, 화합물

생성물 1

HCID 178444406HCID 178444406, 화합물

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 8471Triethylamine용매

실험 절차

A mixture of 0.06 mol of trans-4-pentylcyclohexylacetylene, 0.06 mol of 4-trifluoromethyl-bromobenzene, 250 ml of triethylamine, 1.2 mmol of Pd(II) catalyst and 0.6 mmol of CuI is stirred at room temperature for 15 hours. The reaction mixture is diluted with petroleum ether and filtered. Evaporation and purification give 1-(trans-4-pentylcyclohexyl)-2-(4-trifluoromethylphenyl)acetylene of M.=43°.

후처리

  1. filtrationfiltered
  2. customEvaporation and purification

출처 및 근거

ORD 기록
ord-a7ae0d83fe734c668005c4a7a79eb028
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068053

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