Methyl piperidine-3-carboxylate → HCID 15017107, 화합물

HRID 974163노트

반응식

HRID 974163 반응식
[P:1](=[O:9])([N:6]=[C:7]=[O:8])([S:4][CH3:5])[O:2][CH3:3].[NH:10]1[CH2:15][CH2:14][CH2:13][CH:12]([C:16]([O:18][CH3:19])=[O:17])[CH2:11]1>CCOCC>[CH3:3][O:2][P:1]([NH:6][C:7]([N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([C:16]([O:18][CH3:19])=[O:17])[CH2:11]1)=[O:8])([S:4][CH3:5])=[O:9]

참가 물질

4

반응물 2

HCID 351626Methyl piperidine-3-carboxylateHCID 14879948O,S-dimethyl phosphoroisocyanatidothioate

생성물 1

HCID 15017107HCID 15017107, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 8.36 g of O,S-dimethyl phosphoroisocyanatidothioate in 100 ml of ether was cooled to 0° C. and to it was added dropwise with stirring 7.15 g of methyl 3-piperidinecarboxylate. The mixture was allowed to warm to ambient temperature and react overnight. The precipitate that formed was collected by filtration, extracted with ether, and dried under reduced pressure to obtain 11.5 g (74 percent of theory) of the title compound as white crystals melting at 65°-67° C.

후처리

  1. additionwas added dropwise
  2. customreact overnight
  3. customThe precipitate that formed
  4. filtrationwas collected by filtration
  5. extractionextracted with ether
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-f4959952b8fe4e2482533db7d8143e92
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068230

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