Potassium Carbonate → Tert-butyl 4-ethynylbenzoate

HRID 974208노트

반응식

HRID 974208 반응식
[C:1]([O:5][C:6](=[O:19])[C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([O:5][C:6](=[O:19])[C:7]1[CH:8]=[CH:9][C:10]([C:13]#[CH:14])=[CH:11][CH:12]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 13965007tert-Butyl 4-((trimethylsilyl)ethynyl)benzoate

생성물 1

HCID 13965008Tert-butyl 4-ethynylbenzoate수율 95.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

274.4 g of 4-(trimethylsilylethinyl)-benzoic acid tert.-butyl ester and 12.5 g of anhydrous potassium carbonate in 1.5 l of absolute methanol are stirred together for 3 hours under nitrogen. The reaction mixture is then concentrated by evaporation and worked up with CH2Cl2 /H2O to yield 194 g of 4-ethinyl-benzoic acid tert.-butyl ester.

후처리

  1. concentrationThe reaction mixture is then concentrated by evaporation

출처 및 근거

ORD 기록
ord-39fd856448a04295a5c1912c3375a7ac
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068300

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