Potassium Carbonate → 2-Amino-6-(1H-inden-2-yl-methyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974286

반응식

HRID 974286 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:19][C:20]1[CH2:21][C:22]2[C:27]([CH:28]=1)=[CH:26][CH:25]=[CH:24][CH:23]=2>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:19][C:20]3[CH2:28][C:27]4[C:22]([CH:21]=3)=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:8][CH2:9][C:10]=2[N:11]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 199857932-chloromethyl-1H-indene

생성물 1

HCID 199859752-Amino-6-(1H-inden-2-yl-methyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine수율 4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 2-chloromethyl-1H-indene (prepared from 1H-indene, paraformaldehyde and concentrated hydrochloric acid) in anhydrous dimethylformamide for 2 hours at 50° C. Yield: 4% of theory, Melting point: 134°-138° C.

출처 및 근거

ORD 기록
ord-f628993a88a54087b8da7eda00a08319
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068325

연결된 노트

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