Diisopropyl Ether → HCID 54240092, 화합물

HRID 974335노트

반응식

HRID 974335 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].[Br:18][C:19]1[CH:28]=[CH:27][CH:26]=[CH:25][C:20]=1[CH:21]=[CH:22][CH2:23]Br.C(OC(C)C)(C)C>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:23][CH:22]=[CH:21][C:20]3[CH:25]=[CH:26][CH:27]=[CH:28][C:19]=3[Br:18])[CH2:8][CH2:9][C:10]=2[N:11]=1

참가 물질

6

반응물 4

HCID 7914Diisopropyl EtherHCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53688271o-Bromocinnamylbromide

생성물 1

HCID 54240092HCID 54240092, 화합물수율 42%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared analogously to Example 1 from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 2-bromo-cinnamyl bromide in anhydrous dimethylformamide for 2 hours at 20° C. Yield: 42% of theory, Melting point: 103°-106° C. (diisopropylether).

출처 및 근거

ORD 기록
ord-ea78143dc56d4c898a458d47f0192369
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068325

반응 노트

불러오는 중…