Potassium Carbonate → HCID 54514614, 화합물

HRID 974336노트

반응식

HRID 974336 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].[F:18][C:19]([F:31])([F:30])[C:20]1[CH:21]=[C:22]([CH:27]=[CH:28][CH:29]=1)[CH:23]=[CH:24][CH2:25]Br>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:25][CH:24]=[CH:23][C:22]3[CH:27]=[CH:28][CH:29]=[C:20]([C:19]([F:18])([F:30])[F:31])[CH:21]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54572020HCID 54572020, 화합물

생성물 1

HCID 54514614HCID 54514614, 화합물수율 41%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared analogously to Example 1 from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 3-trifluoromethyl-cinnamyl bromide in anhydrous dimethylformamide for one hour at 20° C. Yield: 41% of theory, Melting point: 102°-105° C. (petroleum ether).

출처 및 근거

ORD 기록
ord-819ce6c86a8948829ab494635cf2eb1f
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068325

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