Potassium Carbonate → HCID 54346962, 화합물
반응식
Cl[CH2:2][C:3]([CH3:17])([CH3:16])[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=1[F:15])=[O:5].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[CH3:2][C:3]1([CH3:17])[CH2:16][N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[F:15])[C:4]1=[O:5]참가 물질
4
반응 조건
- 온도
- 75 °C
실험 절차
49.7 g (0.19 mol) of 3-chloro-2,2-dimethyl-N-[(2,4-difluorophenyl)methyl]propanamide and 78.8 g (0.57 mol) of potassium carbonate are suspended in 200 ml of methyl ethyl ketone, and the suspension is warmed and stirred at 75° C. for 24 hours. When the reaction is complete (GC check), the mixture is filtered, and the filtrate is evaporated on a vacuum rotary evaporator. 40.9 g (95% of theory) of a yellow oil are obtained.
후처리
- temperaturethe suspension is warmed
- filtrationthe mixture is filtered
- customthe filtrate is evaporated on a vacuum rotary evaporator
- custom40.9 g (95% of theory) of a yellow oil are obtained
출처 및 근거
- ORD 기록
- ord-3a4addd6971d49d5955b43b04fb7c208
- 출처 데이터셋
- uspto-grants-1991_11
- 특허 번호
- US05068371
반응 노트
불러오는 중…