Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(Triphenylphosphoranylidene)acetaldehyde → 5,5-Bis(2-fluoro-4-methylphenyl)-4-(1-methyl-1H-tetrazol-5-yl)-2,4-pentadienal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (Triphenylphosphoranylidene)acetaldehyde | HCID 75051 | — |
| 반응물 | 3,3-Bis(2-fluoro-4-methylphenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenal | HCID 14723994 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 5,5-Bis(2-fluoro-4-methylphenyl)-4-(1-methyl-1H-tetrazol-5-yl)-2,4-pentadienal | HCID 54207376 | 89.9% |
반응 단계
A solution of 3,3-bis(2-fluoro-4-methylphenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenal (1.35 g, 3.8 mmoles) and triphenylphosphoranylidene acetaldehyde (1.16 g, 3.8 mmoles) in benzene was heated at reflux for 3 hours. The solvent was removed and the residue purified by column chromatography on silica gel eluting with 1% (v/v) methanol in methylene chloride. The fractions containing material having Rf =0.9 [methanol-methylene chloride; 1.20 (v/v)] were combined and concentrated to give 1.3 g of the title compound; m.p.=88°-108° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05068346 |
| 출처 데이터셋 | uspto-grants-1991_11 |
| ORD ID | ord-ab43328880904e13ae634977a4284a12 |
| 출처 메모 | uspto-grants-1991_11 |