Water → Meridia

HRID 974527노트

반응식

HRID 974527 반응식
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[OH2:21]>C1(C)C=CC=CC=1>[OH2:21].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

참가 물질

4

반응물 2

HCID 962WaterHCID 64764Sibutramine Hydrochloride

생성물 1

HCID 64765Meridia

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (5 g) was dissolved in a boiling mixture of toluene (126 ml) and water (12.6 ml). The solution was filtered whilst hot and the filtrate cooled. The product crystallised from the cooled filtrate and was collected by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 194°-196° C.).

후처리

  1. filtrationThe solution was filtered whilst hot and the filtrate
  2. temperaturecooled
  3. customThe product crystallised from the cooled filtrate
  4. filtrationwas collected by filtration
  5. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-eada22b79e60499c897fdf45035a69b7
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068440

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