Acetone → Meridia

HRID 974528노트

반응식

HRID 974528 반응식
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].CC(C)=[O:23]>O>[OH2:23].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

참가 물질

4

반응물 2

HCID 180AcetoneHCID 64764Sibutramine Hydrochloride

생성물 1

HCID 64765Meridia

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (10 g) was dissolved in a boiling mixture of acetone (110 ml) and water (1.2 ml). The solution was filtered whilst hot and the volume of the filtrate reduced by the removal by distillation of 80 ml of solvent. The product was collected from the cooled concentrate by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 195° C.).

후처리

  1. filtrationThe solution was filtered whilst hot and the volume of the filtrate
  2. customreduced by the removal by distillation of 80 ml of solvent
  3. customThe product was collected from the cooled
  4. concentrationconcentrate by filtration
  5. customdried in vacuo at ambient temperature

출처 및 근거

ORD 기록
ord-99c3114c5f71476ea11f27980dc46c35
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068440

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