Water → Meridia

HRID 974529노트

반응식

HRID 974529 반응식
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[OH2:21]>>[OH2:21].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

참가 물질

3

반응물 2

HCID 962WaterHCID 64764Sibutramine Hydrochloride

생성물 1

HCID 64765Meridia

실험 절차

A sample (1 g) of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride which had been dehydrated in vacuo at 70° C. for 7 hours was dissolved in a boiling mixture of water (0.5 ml) and an organic solvent (4.5 ml). The solution was allowed to cool to ambient temperature and then stored at 4° C. for three hours. A solid was collected by filtration, washed with the organic solvent and dried in vacuo at ambient temperature for 18 hours to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate the melting point of which is given below.

후처리

  1. filtrationA solid was collected by filtration
  2. washwashed with the organic solvent
  3. customdried in vacuo at ambient temperature for 18 hours

출처 및 근거

ORD 기록
ord-9de75bd130cd45eda8d7a7840f5de423
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05068440

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